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Madras et al (2006) in the latest paper shown in vivo binding of modafinil to striatal DAT and thalamic Web in rhesus monkeys working with PET imaging. The investigators as opposed binding in the DAT probe [11C]CFT and the Web probe [11C]MeNER from the absence of modafinil with the binding of these probes while in the existence of modafinil to work